Application of the CARE Guideline as reporting standard in the Stem Cell Investigation

The Stem Cell Investigation welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to practitioners in the fields of medicine.

For completeness and transparency for published case reports, the Stem Cell Investigation will apply the CARE guidelines (1) as reporting standards for case reports starting from October 14, 2019. For any submission of case report after the date:

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Cutaneous metastases of breast cancer during adjuvant chemotherapy correlates with increasing CD44+/CD24− and ALDH-1 expression: a case report and literature review

Figure 2 Double immunohistochemical analyses of CD44 (red)/CD24 (brown), and single IHC stain of ALDH-1 in breast cancers of case 2 (magnification ×200, scale bar 100 µm). Expressions of CD44/CD24 (A) and ALDH-1 (B) in primary breast cancer. Expressions of CD44/CD24 (C) and ALDH-1 (D) in cutaneous metastatic ductal carcinoma.

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Targeting chronic myeloid leukemia stem cells: can transcriptional program be a druggable target for cancers?

Figure 1 Simplified model of Wnt/β-catenin and related signaling and proposed model of PGE1 activity in CML. 

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Organoids recapitulate organs?

Figure 1 To obtain intestinal epithelium, activin A could be used to differentiate hPSC into definitive endoderm (DE). This SOX17-positive DE could be differentiated into foregut, midgut, and hindgut. The SOX2-positive foregut gives rise to stomach (HGO), while the CDX2-positive midgut and hindgut give rise to the small (HIO) and large intestines (HCO), respectively. These regional identities were originated by several signaling factors, such as WNTs, FGFs, and BMPs. hPSC, human pluripotent stem cell; FGFs, fibroblast growth factors; BMPs, bone morphogenetic proteins.

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Breast cancer stem cells—from origins to targeted therapy

Breast cancer is one of the most common causes of cancer-related deaths in women worldwide. Gratifyingly, improvement in recent advances of breast cancer screening methods and treatment strategies such as chemotherapy and radiotherapy contribute to a significant eradication of primary tumour bulk, thereby increasing chances of survival for breast cancer patients.

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Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of non-arteritic ischemic optic neuropathy (NAION)

Non-arteritic Ischemic Optic Neuropathy (NAION) is an ischemic, non-inflammatory process involving the prelaminar, laminar and retrolaminar optic nerve. In the United States, the annual incidence of NAION is 2.3 to 10.2 per 100,000 population.

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Stem cell extracellular vesicles and kidney injury

The acute and chronic loss of renal function are interrelated syndromes with a rising incidence as well as poor treatment outcomes and high-related costs. Acute kidney injury (AKI) is characterized by a rapid decline of renal function and associates with an increase of mortality and hospitalization.

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Alopecia and platelet-derived therapies

Hair loss disorders, such as androgenetic alopecia (AGA), display relatively high rates of occurrence in both men and women. Fifty percent of white men will experience some degree of AGA, also known as male-pattern baldness or MPHL, by age 50, and nearly 50% of women will experience AGA (female-pattern hair loss, FPHL) over the course of her lifetime.

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