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Adipose-derived stem cells and their microenvironment (Niche) in type 2 diabetes mellitus

The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction, which contains adipose tissue stem cells, is an alternative therapy that is developed to overcome T2DM.

Cell pausing method for adipose tissue derived mesenchymal stem cells: comparison of Petaka G3 and ordinary flask

Various methods of cell pausing were applied to prevent proliferation of cultured cells, which either required special medium, using complicated encapsulation method, or using a special flask (Petaka G3 flask).

CD44 expression in stem cells and niche microglia/macrophages following ischemic stroke

CD44 is expressed in stem cells and cells in the niches surrounding them, including inflammatory cells, suggesting that CD44 may play an important role in reparative processes within ischemic areas under neuroinflammatory conditions; in particular, strokes.

Impact of maternal and neonatal factors on umbilical cord CD34⁺ cells

The achievement of optimal number of CD34⁺ umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34⁺ cell count.

SCI Annual Report (2019)

Greetings from Dr. Zhizhuang Zhao, Dr. Delong Liu and the Editorial Office of SCI!

We are glad to present the 2019 Annual Report of SCI. There were 44 articles published in SCI and the total retrieval of the journal in PubMed has increased in the past 2019. More information is shown in the Annual Report.

Application of the CARE Guideline as reporting standard in the Stem Cell Investigation

The Stem Cell Investigation welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to practitioners in the fields of medicine.

For completeness and transparency for published case reports, the Stem Cell Investigation will apply the CARE guidelines (1) as reporting standards for case reports starting from October 14, 2019. For any submission of case report after the date:

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Brief Report

Clocking the circadian genes in human embryonic stem cells

Soumyaa Thakur, Prachi Storewala, Upasna Basak, Nitya Jalan, Prasad Pethe

Stem Cell Investigation

2020;

(15 May 2020)

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Review Article

Current state of stem cell-based therapies: an overview

Riham Mohamed Aly

Stem Cell Investigation

2020;

(15 May 2020)

PDF Full Text COI Form Open Access

Review Article

Role of endothelial progenitor cells in vascular development, homestatic maintenance of blood vessels and in injury-mediated reparative response

Ugo Testa, Germana Castelli, Elvira Pelosi

Stem Cell Investigation

2020;

(30 April 2020)

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Brief Report

The effect of short-term necrostatin-1 treatment on the differentiation of human induced pluripotent stem beta cells

Hien Lau, Soomin Park, Colleen Luong, Nicole Corrales, Samuel Rodriguez, Shiri Li, Michael Alexander, Jonathan R. T. Lakey

Stem Cell Investigation

2020;

(16 April 2020)

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Original Article

Impact of maternal and neonatal factors on umbilical cord CD34⁺ cells

Mohamed A. Rowisha, Mohamed R. El-Shanshory, Eslam E. El-Hawary, Amira Youssef Ahmed, Shafeq Ryad Mustafa Altoraky

Stem Cell Investigation

2020;

(31 March 2020)

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Original Article

CD44 expression in stem cells and niche microglia/macrophages following ischemic stroke

Rikako Sawada, Akiko Nakano-Doi, Tomohiro Matsuyama, Nami Nakagomi, Takayuki Nakagomi

Stem Cell Investigation

2020;

(10 March 2020)

PDF Full Text Open Access

Review Article

The role of exosomal microRNAs in pancreatic cancer

Yifan Xu, Xiaohui Xu, Abigael Williams, Weiqun Ding

Stem Cell Investigation

2020;

(28 February 2020)

PDF Full Text Open Access

Review Article

Adipose-derived stem cells and their microenvironment (Niche) in type 2 diabetes mellitus

Karina, Jeanne A. Pawitan, Imam Rosadi

Stem Cell Investigation

2020;

(19 February 2020)

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Original Article

Cell pausing method for adipose tissue derived mesenchymal stem cells: comparison of Petaka G3 and ordinary flask

Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Tera Dria Kispa, Evah Luviah, Fajar Mujadid, Novialdi Novialdi

Stem Cell Investigation

2020;

(19 February 2020)

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Review Article

Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis

Mohammadmahdi Jafarzadeh Bejargafshe, Mohammad Hedayati, Sahar Zahabiasli, Eisa Tahmasbpour, Saeed Rahmanzadeh, Amir Nejad-Moghaddam

Stem Cell Investigation

2019;

(27 December 2019)

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Review Article

Cancer stem cells: progress and challenges in lung cancer

Amanda K. Templeton, Shinya Miyamoto, Anish Babu, Anupama Munshi, Rajagopal Ramesh

Recent advances and novel agents for FLT3 mutated AML

Rahul Pawar, Omar Preet Singh Bali, Bharat Kumar Malhotra, Gurpreet Lamba

Regulatory factors of induced pluripotency: current status

Wei Zhao, Bo Ning, Chen Qian

TNF-α, a good or bad factor in hematological diseases?

Tian Tian, Min Wang, Daoxin Ma

Reactive oxygen species in eradicating acute myeloid leukemic stem cells

Hui Zhang, Hai Fang, Kankan Wang

MicroRNAs as biomarkers in leukemia

Xinxin Wang, Baohua Zhu, Zunnan Huang, Liyong Chen, Zhiwei He, Hua Zhang

Regulation of cancer stem cells by RING finger ubiquitin ligases

Bin Kang, Xiao-Hong Sun

Cancer stem cells as a potential therapeutic target in breast cancer

Mingzhi Zhang, Zhaoming Li, Xudong Zhang, Yu Chang

Commentary

Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

Yamei Chen, Delong Liu

Case Report

Cutaneous metastasis as an initial presentation of lung adenocarcinoma with KRAS mutation: a case report and literature review

Huijuan Liao, Shenhong Wu, Stephen R. Karbowitz, Nora Morgenstern, David R. Rose

Review Article

TNF-α, a good or bad factor in hematological diseases?

Tian Tian, Min Wang, Daoxin Ma

Reactive oxygen species in eradicating acute myeloid leukemic stem cells

Hui Zhang, Hai Fang, Kankan Wang

Cancer stem cells as a potential therapeutic target in breast cancer

Mingzhi Zhang, Zhaoming Li, Xudong Zhang, Yu Chang

MicroRNAs as biomarkers in leukemia

Xinxin Wang, Baohua Zhu, Zunnan Huang, Liyong Chen, Zhiwei He, Hua Zhang

The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute

Jilong Yang, Zhiwu Ren, Xiaoling Du, Mengze Hao, Wenya Zhou

Targeting cancer stem cells with oncolytic virus

Yin Tong, Wenbin Qian

Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation

Tianyu Guo, Xuejun Wang, Yigong Qu, Yu Yin, Tao Jing, Qing Zhang

Cancer stem cells and exosome signaling

Bethany N. Hannafon, Wei-Qun Ding

Interplay of retinal determination gene network with TGF-β signaling pathway in epithelial-mesenchymal transition

Yu Liu, Deguang Kong, Hua Wu, Xun Yuan, Hanxiao Xu, Cuntai Zhang, Gaosong Wu, Kongming Wu

Expression and function of P2 receptors in hematopoietic stem and progenitor cells

Wenli Feng, Lina Wang, Guoguang Zheng

Current insights into the diagnosis and treatment of inherited bone marrow failure syndromes in China

Xiaofan Zhu

Research Highlights

Shp2 regulates leukemic stem cell frequency in MLL-rearranged acute myeloid leukemia

Jie Wu

Editorial

Stem nourished by branches: glioblastomas co-opt classic neurotrophic factor signaling to maintain stem-like cell pool

Rukayat Taiwo, Tatenda Mahlokozera, Albert H. Kim

Evolutionarily diverse mechanisms of germline specification among mammals: what about us?

Shino Mitsunaga, Toshi Shioda

Epigenomic and single-cell profiling of human spermatogonial stem cells

Akihiko Sakashita, Yu-Han V. Yeh, Satoshi H. Namekawa, Shau-Ping Lin

The puzzling mechanism of compensatory lung growth

Steven J. Mentzer

Vaccination with induced pluripotent stem cells confers protection against cancer

Kavitha Yaddanapudi, Chi Li, John W. Eaton

Commentary

Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

Yamei Chen, Delong Liu

Case Report

Isolated factor V deficiency in a patient with elevated PT and aPTT during routine pre-operative laboratory screening

Keyur Thakar, Kaushal Parikh, Yamei Chen, Delong Liu

Original Article

Protein kinase C delta (PKCδ) splice variant modulates senescence via hTERT in adipose-derived stem cells

Gay Carter, Rekha Patel, André Apostolatos, Michel Murr, Denise R. Cooper, Niketa A. Patel

Reverse transcriptase and intron number evolution

Kemin Zhou, Alan Kuo, Igor V. Grigoriev

Interleukin 8/KC enhances G-CSF induced hematopoietic stem/ progenitor cell mobilization in Fancg deficient mice

Yan Li, Wen Xing, Yong-Zheng He, Shi Chen, Steven D. Rhodes, Jin Yuan, Yuan Zhou, Jun Shi, Jie Bai, Feng-Kui Zhang, Wei-Ping Yuan, Tao Cheng, Ming-Jiang Xu, Feng-Chun Yang

Quantitative analyses of myelofibrosis by determining hydroxyproline

Wanke Zhao, Wan-Ting Tina Ho, Zhizhuang Joe Zhao

Journal Highlight more

Stem Cell Investigation is an international, open access, peer-reviewed, PubMed-indexed online journal covering basic, translational, and clinical research on all aspects of stem cells, e.g. embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine.