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2017 Annual Report of SCI

Here we are glad to present the 2017 Annual Report of SCI. During 2017, SCI reached several new milestones. Four focused issues have been officially published, which is a remarkable progress for SCI. Download of SCI articles on PubMed has been increasing steadily, with a total of 79,700 times by December. More information is shown in the Annual Report.

We give our sincere thanks to all our editorial board members, guest editors, reviewers, authors and readers. We wish you a happy, healthy and prosperous 2018!

Breast cancer stem cells—from origins to targeted therapy

Breast cancer is one of the most common causes of cancer-related deaths in women worldwide. Gratifyingly, improvement in recent advances of breast cancer screening methods and treatment strategies such as chemotherapy and radiotherapy contribute to a significant eradication of primary tumour bulk, thereby increasing chances of survival for breast cancer patients.

Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of non-arteritic ischemic optic neuropathy (NAION)

Non-arteritic Ischemic Optic Neuropathy (NAION) is an ischemic, non-inflammatory process involving the prelaminar, laminar and retrolaminar optic nerve. In the United States, the annual incidence of NAION is 2.3 to 10.2 per 100,000 population.

Stem cell extracellular vesicles and kidney injury

The acute and chronic loss of renal function are interrelated syndromes with a rising incidence as well as poor treatment outcomes and high-related costs. Acute kidney injury (AKI) is characterized by a rapid decline of renal function and associates with an increase of mortality and hospitalization.

Alopecia and platelet-derived therapies

Hair loss disorders, such as androgenetic alopecia (AGA), display relatively high rates of occurrence in both men and women. Fifty percent of white men will experience some degree of AGA, also known as male-pattern baldness or MPHL, by age 50, and nearly 50% of women will experience AGA (female-pattern hair loss, FPHL) over the course of her lifetime.

Aplastic anemia is related to alterations in T cell receptor signaling

Aplastic anemia (AA) is a disease characterized by bone marrow hematopoietic dysfunction and peripheral blood pancytopenia, which is thought to be mediated by an abnormal T cell-induced immune response. T cell receptor (TCR) signaling is pivotal for T cell development and function. An aberrant TCR signaling leads to an unbalanced immune system that can result in a range of immune-related disorders, including autoimmune diseases, chronic infections, and tumors.

Indoleamine 2,3-dioxygenase and survivin peptide vaccine combined with temozolomide in metastatic melanoma

Peptide vaccination as therapy of cancer is able to induce robust CD8+ T-cell responses towards a multitude of antigens. However, despite multiple clinical trials, no peptide vaccines have yet reached approval for the treatment of human cancers.

Stem-cell extracellular vesicles and lung repair

Four out of the ten leading causes of morbidity and mortality worldwide are lung diseases. Despite advances in comprehending the pathophysiological mechanisms involved in these disorders, for several respiratory diseases, there is still no effective treatment able to stop their natural history or reverse the morphological and functional damage they cause.

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