Editing genetics, stem cells are prophetic, what’s the best way to model cells of diabetics?

Marissa A. Scavuzzo, Malgorzata Borowiak


The pancreas is composed of many different cell types, including the endocrine beta cells that are lost or dysfunctional in those afflicted with diabetes. Beta cells normally sense the level of glucose in the blood and secrete an appropriate amount of insulin in response, which binds to receptors on peripheral tissues like muscle and fat to induce glucose uptake. Current treatments for diabetics hinge on constant injections of external insulin, leaving large fluctuations in blood glucose levels and devastating consequences such as kidney failure and retinopathy.