TY - JOUR AU - Fathi, Ezzatollah AU - Charoudeh, Hojjatollah Nozad AU - Sanaat, Zohreh AU - Farahzadi, Raheleh PY - 2019 TI - Telomere shortening as a hallmark of stem cell senescence JF - Stem Cell Investigation; Vol 6 (March 2019): Stem Cell Investigation Y2 - 2019 KW - N2 - Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through multi-lineage differentiation, self-renewal properties, etc. Despite the above advantages of MSCs, the defined properties of these cells are strongly affected by aging. Thus, the use of MSCs from older donors is lower than younger one, which limits clinical applications in cell therapy. According to the theories of aging, it is determined that aging is most likely caused by telomere shortening and telomere shortening is considered hallmarks of aging. Finding out the most mechanisms of these changes will probably reveal novel therapeutic targets for prolonging human health and for ameliorating age-associated phenotypes. This review focuses on prevalent knowledge about the mechanisms of stem cell senescence by telomere shortening and the molecular mechanism details involved in it. UR - https://sci.amegroups.org/article/view/24385