TY - JOUR AU - Xiao, Yankai AU - Zhao, Suwen AU - Li, Bo PY - 2017 TI - Aplastic anemia is related to alterations in T cell receptor signaling JF - Stem Cell Investigation; Vol 4, No 10 (October 2017): Stem Cell Investigation Y2 - 2017 KW - N2 - Aplastic anemia (AA) is a disease characterized by bone marrow hematopoietic dysfunction and peripheral blood pancytopenia, which is thought to be mediated by an abnormal T cell-induced immune response. T cell receptor (TCR) signaling is pivotal for T cell development and function. An aberrant TCR signaling leads to an unbalanced immune system that can result in a range of immune-related disorders, including autoimmune diseases, chronic infections, and tumors. In this article, we briefly review the T cell immune pathophysiology of AA, the physiology of normal TCR signaling and its regulatory factors, and clinical and laboratory findings of TCR signaling molecules and their regulatory factors in AA. UR - https://sci.amegroups.org/article/view/17061