%0 Journal Article %T Graft predominance after double umbilical cord blood transplantation: a review %A Cornelissen, Jan J. %A Kalin, Burak %A Lamers, Cor H. J. %J Stem Cell Investigation %D 2017 %B 2017 %9 %! Graft predominance after double umbilical cord blood transplantation: a review %K %X Several parameters are involved in graft predominance after double umbilical cord blood transplantation (dUCBT), of which T-cell alloreactivity between the grafts is now considered to be the major denominator. We recently showed that alloreactive CD4+ T-cells originating from the predominant CBU recognize HLA-class II allele mismatches and can readily be detected in the majority of patients. In addition, it was shown that HLA-class II allele-specific CD4+ T-cells were able to recognize primary leukemic cells when the mismatched HLA-class II allele was shared between the rejected CBU and the patient. These results further underscored the role of alloreactive T-cells, notably class II specific CD4+ T-cells, in graft-versus-graft reactions and in graft-versus-leukemia after dUCBT. %U https://sci.amegroups.org/article/view/15028 %V 4 %N 5 %P %@ 2313-0792