%0 Journal Article %T Study of peripheral stem cells mobilization as a treatment line of pediatric dilated cardiomyopathy %A El-Shanshory, Mohamed %A El-Shehaby, Waled %A Hables, Nahed %A Hamad, Said %A Attia, Mohamed %A El-Said, Ayman %J Stem Cell Investigation %D 2015 %B 2015 %9 %! Study of peripheral stem cells mobilization as a treatment line of pediatric dilated cardiomyopathy %K %X Background: Mobilizing hematopoietic stem cells may be a promising intervention for the treatment of idiopathic dilated cardiomyopathy (IDCM) in infant and children. So the aim of the work is to evaluate the efficacy of granulocyte-colony stimulating factor (G-CSF) as a therapeutic modality in pediatric IDCM. Methods: A randomized clinical trial was conducted on 40 pediatric patients with IDCM. They were subjected to history taking, clinical examination, serum lactate dehydrogenase (LDH), total creatinine phosphokinase (CPK), creatinine phosphokinase isoenzyme B (CK-MB) isoenzyme, and peripheral blood CD34 + cell assessment before and at day 7 after subcutaneous G-CSF injection for 5 consecutive days. Echocardiography was done before and 1, 3 and 6 months after therapy. Results: Clinical improvement in the form of regression of patients Modified Ross heart failure (MRHC) classification classes. Increased percentage of CD34 + mobilized cells from the bone marrow, and significant increase in blood counts especially white blood cells 7 days after G-CSF injection. Significant improvement was found in echocardiographic data evaluating systolic function of the heart [Ejection fraction, Fractional shortening and systolic velocity at mitral annulus (Sm)]. Conclusions: Administration of G-CSF may be beneficial in improving systolic functions of the heart in pediatric IDCM and more studies with a large number of patients are needed. %U https://sci.amegroups.org/article/view/8415 %V 2 %N 11 %P %@ 2313-0792