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Interleukin 8/KC enhances G-CSF induced hematopoietic stem/ progenitor cell mobilization in Fancg deficient mice

	author = {Yan Li and Wen Xing and Yong-Zheng He and Shi Chen and Steven D. Rhodes and Jin Yuan and Yuan Zhou and Jun Shi and Jie Bai and Feng-Kui Zhang and Wei-Ping Yuan and Tao Cheng and Ming-Jiang Xu and Feng-Chun Yang},
	title = {Interleukin 8/KC enhances G-CSF induced hematopoietic stem/ progenitor cell mobilization in  Fancg  deficient mice},
	journal = {Stem Cell Investigation},
	volume = {1},
	number = {10},
	year = {2014},
	keywords = {},
	abstract = {Background: Fanconi anemia (FA) is a heterogeneous genetic disorder characterized by a progressive bone marrow aplasia, chromosomal instability, and acquisition of malignancies. Successful hematopoietic cell transplantation (HCT) for FA patients is challenging due to hypersensitivity to DNA alkylating agents and irradiation of FA patients. Early mobilization of autologous stem cells from the bone marrow has been thought to be ideal prior to the onset of bone marrow failure, which often occurs during childhood. However, the markedly decreased response of FA hematopoietic stem cells to granulocyte colony-stimulating factor (G-CSF) is circumventive of this autologous HCT approach. To-date, the mechanism for defective stem cell mobilization in G-CSF treated FA patients remains unclear.
Methods: Fancg heterozygous (Fancg+/–) mice utilized in these studies. Student’s t-test and one-way ANOVA were used to evaluate statistical differences between WT and Fancg–/– cells. Statistical significance was defined as P values less than 0.05.
Results: Fancg deficient (Fancg–/–) mesenchymal stem/progenitor cells (MSPCs) produce significant lower levels of KC, an interleukin-8 (IL-8) related chemoattractant protein in rodents, as compared to wild type cells. Combinatorial administration of KC and G-CSF significantly increased the mobilization of hematopoietic stem/progenitor cells (HSPCs) in Fancg–/– mice.
Conclusions: In summary, our results suggest that KC/IL-8 could be proved useful in the synergistic mobilization of FA HSPCs in combination with G-CSF.},
	issn = {2306-9759},	url = {}