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Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

  
@article{SCI3604,
	author = {Yamei Chen and Delong Liu},
	title = {Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights},
	journal = {Stem Cell Investigation},
	volume = {1},
	number = {4},
	year = {2014},
	keywords = {},
	abstract = {Hematopoietic stem cells (HSCs) can take one of the three different pathways: quiescence, self-renewal and differentiation. Mechanisms that control the tight balance to maintain lifelong hematopoietic homeostasis have been a major interest of research. Platelet factor-4 (PF4), a weak chemokine, is synthesized exclusively by megakaryocytes and sequestered in platelets. This meeting report highlights a novel study presented at 2013 ASH annual meeting. This study found that megakaryocyte, a progeny of HSC, was involved in maintaining quiescence of HSCs via PF4 in a feedback loop.},
	issn = {2306-9759},	url = {http://sci.amegroups.com/article/view/3604}
}