TY - JOUR AU - Meganathan, Kesavan AU - Prakasam, Ramachandran AU - Kroll, Kristen L. PY - 2019 TI - A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells JF - Stem Cell Investigation; Vol 6 (May 2019): Stem Cell Investigation Y2 - 2019 KW - N2 - A transcriptionally permissive chromatin state is a characteristic of both the early blastocyst embryo and of embryonic stem cells (ESCs). Recent work from the laboratory of Miguel Ramalho-Santos, described in this Editorial, demonstrates that this state is very sensitive to translational output, with a positive feedback loop linking high rates of translation with maintenance of a stem cell state of hyper-transcription and elevated chromatin accessibility (1). UR - https://sci.amegroups.org/article/view/25797