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A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells

  
@article{SCI25797,
	author = {Kesavan Meganathan and Ramachandran Prakasam and Kristen L. Kroll},
	title = {A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells},
	journal = {Stem Cell Investigation},
	volume = {6},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {A transcriptionally permissive chromatin state is a characteristic of both the early blastocyst embryo and of embryonic stem cells (ESCs). Recent work from the laboratory of Miguel Ramalho-Santos, described in this Editorial, demonstrates that this state is very sensitive to translational output, with a positive feedback loop linking high rates of translation with maintenance of a stem cell state of hyper-transcription and elevated chromatin accessibility (1).},
	issn = {2306-9759},	url = {http://sci.amegroups.com/article/view/25797}
}