TY - JOUR AU - Wang, Jiasheng AU - Hu, Yongxian AU - Huang, He PY - 2018 TI - Current development of chimeric antigen receptor T-cell therapy JF - Stem Cell Investigation; Vol 5 (December 2018): Stem Cell Investigation Y2 - 2018 KW - N2 - Chimeric antigen receptor (CAR) T-cell therapy has achieved great success in recent years, with encouraging complete remission rate and long-term durability of response, especially in advanced B-cell malignancies. With the approval of tisagenlecleucel and axi-cel by FDA to treat refractory/relapsed acute lymphoblastic leukemia and non-Hodgkin lymphoma, our understanding of CAR T cells has been progressing rapidly. In this review, we discussed the designs of CAR T cells, factors affecting response, adverse effects, as well as application beyond B-cell malignancies. UR - https://sci.amegroups.org/article/view/22694