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Current development of chimeric antigen receptor T-cell therapy

	author = {Jiasheng Wang and Yongxian Hu and He Huang},
	title = {Current development of chimeric antigen receptor T-cell therapy},
	journal = {Stem Cell Investigation},
	volume = {5},
	number = {0},
	year = {2018},
	keywords = {},
	abstract = {Chimeric antigen receptor (CAR) T-cell therapy has achieved great success in recent years, with encouraging complete remission rate and long-term durability of response, especially in advanced B-cell malignancies. With the approval of tisagenlecleucel and axi-cel by FDA to treat refractory/relapsed acute lymphoblastic leukemia and non-Hodgkin lymphoma, our understanding of CAR T cells has been progressing rapidly. In this review, we discussed the designs of CAR T cells, factors affecting response, adverse effects, as well as application beyond B-cell malignancies.},
	issn = {2306-9759},	url = {}