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Picture of glioma stem cells has become a Notch brighter

  
@article{SCI22502,
	author = {Prahlad Parajuli and Sandeep Mittal},
	title = {Picture of glioma stem cells has become a Notch brighter},
	journal = {Stem Cell Investigation},
	volume = {5},
	number = {0},
	year = {2018},
	keywords = {},
	abstract = {Solid tumors often behave like an organ system, comprised of rapidly proliferating cancer cells and a variety of stromal components, including endothelial cells (ECs), fibroblasts, and immune cells. Similar to an organ system, all tumors, including malignant gliomas, also contain a small population of cancer stem cells (CSCs) with adult stem cell-like characteristics, namely, pluripotency and capacity for self-renewal. CSCs are quiescent and have low immunogenicity—features that help them evade destruction by chemotherapy and immunotherapy, respectively. Identification of novel molecular cues that regulate maintenance (self-renewal) of CSCs could help develop new therapeutic interventions for complete eradication of cancer and avoid recurrence.},
	issn = {2306-9759},	url = {http://sci.amegroups.com/article/view/22502}
}