%0 Journal Article %T The STAT3 and hypoxia pathways converge on Vasorin to promote stemness and glioblastoma tumorigenesis through Notch1 stabilization %A Fan, Meiyun %A Pfeffer, Lawrence M. %J Stem Cell Investigation %D 2018 %B 2018 %9 %! The STAT3 and hypoxia pathways converge on Vasorin to promote stemness and glioblastoma tumorigenesis through Notch1 stabilization %K %X Gliomas are the most common primary intracranial neoplasms in adults and a leading cause of cancer-related morbidity and mortality in the United States (1). Grade I gliomas are considered the least malignant brain tumors, and grade IV or GBM the most aggressive and deadliest, which accounts for nearly 75% of all gliomas. Surgical resection of GBM remains the primary treatment modality with present adjuvant chemotherapy and radiation therapy only providing slight improvement in the disease course and outcome (2). %U https://sci.amegroups.org/article/view/21959 %V 5 %P %@ 2313-0792