TY - JOUR AU - Dogliotti, Irene AU - Fava, Carmen AU - Serra, Anna AU - Gottardi, Enrico AU - Daraio, Filomena AU - Carnuccio, Francesca AU - Giugliano, Emilia AU - Bocchia, Monica AU - Saglio, Giuseppe AU - Rege-Cambrin, Giovanna PY - 2017 TI - CALR-positive myeloproliferative disorder in a patient with Ph-positive chronic myeloid leukemia in durable treatment-free remission: a case report JF - Stem Cell Investigation; Vol 4, No 6 (June 2017): Stem Cell Investigation Y2 - 2017 KW - N2 - Current diagnostic criteria for Philadelphia-negative myeloproliferative neoplasia (MPN) have been redefined by the discovery of Janus kinase 2 (JAK2), myeloproliferative leukemia (MPL) and calreticulin (CALR) genetic alterations. Only few cases of coexistence of CALR-mutated MPN and Philadelphia-positive chronic myeloid leukemia (CML) have been described so far. Here we report the case of a patient with CML diagnosed in 2001, treated with imatinib and pegylated interferon (IFN) frontline. She reached complete molecular remission (CMR) and discontinued imatinib, maintaining treatment free remission. Due to persistent thrombocytosis, we repeated bone marrow (BM) analysis and diagnosed CARL-mutated essential thrombocythemia (ET). A CALR-positive clone was found to be present since 2001, and was unaffected by imatinib treatment, possibly representing a molecular abnormality arising at stem cell level. UR - https://sci.amegroups.org/article/view/15365