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CALR-positive myeloproliferative disorder in a patient with Ph-positive chronic myeloid leukemia in durable treatment-free remission: a case report

  
@article{SCI15365,
	author = {Irene Dogliotti and Carmen Fava and Anna Serra and Enrico Gottardi and Filomena Daraio and Francesca Carnuccio and Emilia Giugliano and Monica Bocchia and Giuseppe Saglio and Giovanna Rege-Cambrin},
	title = {CALR-positive myeloproliferative disorder in a patient with Ph-positive chronic myeloid leukemia in durable treatment-free remission: a case report},
	journal = {Stem Cell Investigation},
	volume = {4},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {Current diagnostic criteria for Philadelphia-negative myeloproliferative neoplasia (MPN) have been redefined by the discovery of Janus kinase 2 (JAK2), myeloproliferative leukemia (MPL) and calreticulin (CALR) genetic alterations. Only few cases of coexistence of CALR-mutated MPN and Philadelphia-positive chronic myeloid leukemia (CML) have been described so far. Here we report the case of a patient with CML diagnosed in 2001, treated with imatinib and pegylated interferon (IFN) frontline. She reached complete molecular remission (CMR) and discontinued imatinib, maintaining treatment free remission. Due to persistent thrombocytosis, we repeated bone marrow (BM) analysis and diagnosed CARL-mutated essential thrombocythemia (ET). A CALR-positive clone was found to be present since 2001, and was unaffected by imatinib treatment, possibly representing a molecular abnormality arising at stem cell level.},
	issn = {2306-9759},	url = {http://sci.amegroups.com/article/view/15365}
}