TY - JOUR AU - Wehbe, Terek AU - Saab, Majid Abi AU - Chahine, Nassim Abi AU - Margossian, Talar PY - 2016 TI - Mesenchymal stem cell therapy for refractory scleroderma: a report of 2 cases JF - Stem Cell Investigation; Vol 3, No 9 (September 2016): Stem Cell Investigation Y2 - 2016 KW - N2 - We treated 2 patients with progressive, refractory scleroderma with a combined immunotherapy approach using plasmapheresis followed by rituximab and then intravenous umbilical-cord-derived allogeneic mesenchymal stem cells (MSCs). Both patients improved subjectively and objectively for over a year. Upon recurrence of their symptoms, the patients were treated again with allogeneic MSCs alone with a very good response. The combination was well tolerated and effective suggesting a large scale study may be warranted in progressive, refractory Scleroderma. UR - https://sci.amegroups.org/article/view/11699