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Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence

  
@article{SCI10757,
	author = {Léo Machado and Frédéric Relaix},
	title = {Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence},
	journal = {Stem Cell Investigation},
	volume = {3},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {In this report, Boonsanay and colleagues describe a novel mechanism of maintenance of skeletal muscle stem cells [also known as satellite cells (SCs)] quiescence via the di-methyltransferase Suv4-20h1, regulator of heterochromatin formation. Conditional ablation of Suv4-20h1 in SCs leads notably to the loss of the histone modification H4K20me2 on the distal regulatory element of Myod combined with a relocation of the Myod locus toward a central position in the nucleus. This switch in nuclear compartment is correlated with decreased facultative H3K27me3 associated heterochromatin, and an increase in spontaneously activated MYOD-expressing SCs in homeostatic muscles. Consequently, Suv4-20h1 knock-out SCs demonstrate compromised stem cell potential, as they fail to efficiently self-renew and replenish the SC pool upon muscle injury. Strikingly, restoring MYOD expression alone rescues the levels of facultative chromatin and reverses the loss-of-quiescence phenotype.},
	issn = {2306-9759},	url = {http://sci.amegroups.com/article/view/10757}
}