Engineered platelets with antithrombotic and antimetastatic properties

Liuting Yu, Zhizhuang Joe Zhao


Platelets are small anucleate blood cells that originally derive from bone marrow megakaryocytes from hematopoietic stem cells through a process known as megakaryopoiesis (1,2). They play an indispensable role in normal hemostasis and thrombosis after injury. When blood vessels are damaged, platelets are exposed to the basement membrane and collagen at the wounding site, rapidly triggering platelet activation and aggregation.