Tuning the chromatin landscape of embryonic stem cells

Diana C. Hargreaves


During implantation, cells of the embryo dramatically increase their proliferation rate. This developmental transition involves increased demand for the synthesis of building blocks needed to support the growth of post-implantation epiblast cells. Embryonic stem cells (ESCs) cultured in serum closely resemble cells of the post-implantation epiblast and similarly exhibit high proliferation rates (1).