SETD7 interacts with other chromatin-modifying factors to regulate cardiac development

Pioneer transcription factors are necessary, but not sufficient, for the transcription of many target genes during development. To carry out their function, these sequence-specific transcription factors usually recruit chromatin-modifying factors to specific enhancers and promoters, which regulate histone post-translational modifications (PTMs) and nucleosome position to facilitate RNA Polymerase II occupancy and transcription of a specific battery of genes.