SETD7 interacts with other chromatin-modifying factors to regulate cardiac development

Scott J. Bultman


Pioneer transcription factors are necessary, but not sufficient, for the transcription of many target genes during development. To carry out their function, these sequence-specific transcription factors usually recruit chromatin-modifying factors to specific enhancers and promoters, which regulate histone post-translational modifications (PTMs) and nucleosome position to facilitate RNA Polymerase II occupancy and transcription of a specific battery of genes.