Article Abstract

Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia

Authors: Sandeep Potluri, Daniel Coleman, Constanze Bonifer

Abstract

Within the hematopoietic system, core binding factor beta (CBFβ) normally forms a complex with the master hematopoietic regulator, RUNX1 (1) and stabilizes its binding to DNA (2).