Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia

Sandeep Potluri, Daniel Coleman, Constanze Bonifer

Abstract

Within the hematopoietic system, core binding factor beta (CBFβ) normally forms a complex with the master hematopoietic regulator, RUNX1 (1) and stabilizes its binding to DNA (2).