WhatsApp com between glioma stem cells and differentiated cells to sustain tumor growth

Chann Lagadec, Robert-Alain Toillon, Xuefen Le Bourhis


Glioblastoma is the most common malignant brain tumor with extremely poor patient survival of approximately 15 months (1). This poor prognosis reflects therapeutic resistance and is attributed, at least in part, to the existence of a subset of cells named glioma stem-like cells (GSCs) (2,3). Numerous studies indicate that glioblastoma is heterogeneous, composing of a rare population of GSCs and more differentiated glioma cells (DGCs).