Cell intrinsic regulation of external hematopoietic stem cell stress

Frank J. T. Staal


Hematopoietic stem cells (HSCs) have the ability to self-renew and generate all lineages of blood cells. Most HSCs are resting in adult life and the balance between differentiation, self-renewal, quiescence and apoptosis is strictly regulated (1). Hence, a wide variety of interconnecting signals operates on HSCs.