Article Abstract

Evolutionarily diverse mechanisms of germline specification among mammals: what about us?

Authors: Shino Mitsunaga, Toshi Shioda


Most of our knowledge on the temporospatial aspects of primordial germ cell (PGC) development in mammalian embryos was obtained through studying laboratory mice (1,2). PGCs are the common precursors of sperm and eggs, and they can be distinguished from their precursors based on their morphological characteristics, migrating activities, and expression of marker molecules.