Article Abstract

Epigenomic and single-cell profiling of human spermatogonial stem cells

Authors: Akihiko Sakashita, Yu-Han V. Yeh, Satoshi H. Namekawa, Shau-Ping Lin


The balance between quiescence and proliferation, self-renewal and differentiation of stem cells is critical for maintaining tissue homeostasis and avoiding premature stem/progenitor cell exhaustion (1,2). Spermatogenesis is a well-characterized stem cell-dependent process.