Article Abstract

PDGFA regulation of dermal adipocyte stem cells

Authors: Guillermo C. Rivera-Gonzalez, Brett A. Shook, Valerie Horsley


Adipose tissue is widely studied for its central role in regulating systemic metabolism and contribution to obesity-related diseases; however, skin resident dermal white adipose tissue (dWAT) also contributes to many aspects of skin function. Skin-resident mature adipocytes are thought to prevent hair growth activation through the secretion of BMP molecules (1). Furthermore, following S. aureus infection, adipose tissue in the skin expands and produces an antibacterial peptide (2). During wound healing, defects in adipogenesis can abrogate fibroblast recruitment into wound beds, leading to defects in extracellular matrix deposition and tissue repair (3). Migration of adipocyte precursors into the wounded area might also contribute to the mesenchymal repopulation of the wounded site (4) and in wounds where hair follicle neogenesis is observed fully functional adipocyte precursors are present (5). These findings highlight the breadth of the role of adipose tissue in the skin.