Biological and clinical insights offered by chemically induced liver progenitors (CLiPs)

Recently, we reported on the generation of liver progenitor-like cells, which we named chemically induced liver progenitors (CLiPs), and proposed a new direction for cell transplantation therapy (1). Tanimizu and Mitaka provided an insightful comment on this report (2). Here, we would like to address some of their valuable comments and provide responses and discussion.