Article Abstract

Deletion with 25 nucleotides of TCRζ gene in T cells from a case with chronic myeloid leukemia

Authors: Yan Li, Jing Lai, Ziwei Liao, Lixin Guo, Bo Li, Kanger Zhu, Yangqiu Li


TCRζ is a transmembrane protein, a component of the T cell receptor (TCR)/CD3 complex, and plays a crucial role in T cell activation (1,2). Previous studies showed that T cell immunodeficiency might be related to decreased expression of TCRζ. The alternatively spliced isoforms of TCRζ 3' untranslated region (3' UTR) in patients with chronic myeloid leukemia (CML) was related to change of T cell activation gene expression pattern, and may be as a novel immunological marker for the evaluation of the CML immune status (3). Recently, we found that polymorphisms/mutations in the TCR ζ 3' UTR can regulate the expression level of TCR ζ (unpublished data). However, little is known the genetic alteration of TCRζ 3' UTR in T cells from patients with CML who showed T cell immunodeficiency.