Article Abstract

TGF-β: a master regulator of the bone marrow failure puzzle in Fanconi anemia

Authors: Paula Río, Juan A. Bueren

Abstract

Fanconi anemia (FA) is a genetic disease mainly characterized by progressive bone marrow failure (BMF), congenital abnormalities, and increased predisposition to cancer (1,2). Although most patients with FA develop BMF generally during childhood, the molecular mechanism underlying BMF has remained elusive for a long time and is still a matter of debate.

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