Getting nervous about regeneration

Daniel T. Montoro, Ethan G. Muhonen, Michael T. Longaker


Tissue regeneration is fundamental to sustaining life, but the multi-tissue regeneration capacity of adult mammals is extremely limited. In a classic model of multi-tissue regeneration, rodents display the capacity to replace amputated distal digit tips that are comprised of many various tissues including bone, muscle, nerve, nail, and skin. The mechanisms by which these various tissues collectively generate a properly patterned replacement digit tip, however, have not been fully elucidated.